The right biologic, first time.

Munus ranks 14+ competing biologics for each IBD patient using integrated immune-pathway phenotype, prior drug-response history, and exposure signature. Precision biologic intelligence for autoimmune medicine.

The problem

55–70% of IBD patients don't respond to their first biologic.[1]

Phase 3 trials show 30–45% clinical remission on first-line biologics[1] — the majority of patients cycle drugs before finding what works. Each failed prescription costs the payer $30–50K and the patient 6–12 months of active disease per drug cycled.[2] Pharma loses brand share to competitors at every non-responder switch. No commercial decision-support tool exists for biologic selection in autoimmune medicine.

$30–40B
Global IBD biologic spend / yr[3]
Plus $150–200B adjacent autoimmune.
50–65%
First-line failure rate[1]
Patients cycle 2–3 drugs before remission.
$8–12B
US biologic spend + downstream / yr[2]
Drug spend on non-responders plus surgery costs.
+5–7%
YoY disease growth[4]
Pediatric IBD up 8–10%/yr globally.
The solution

A clinical reasoning engine that ranks biologic candidates per patient.

Munus integrates immune-pathway phenotype (Th1, Th17, NF-κB, NLRP3), prior drug-response history, exposure signature, and symptom pattern into a multi-modal inference model. Output: ranked biologic candidates with mechanism-aligned rationale, exported as a prior-auth-ready clinical brief. Decision support, not diagnosis.

Step 1

Upload chart

Drop patient files (PDF, DOCX, DICOM). Munus de-identifies automatically and extracts structured findings from unstructured records.

Step 2

Review match

Algorithm produces a ranked list of biologic candidates with mechanism-aligned rationale. Top match plus alternatives, each with supporting clinical reasoning.

Step 3

Prescribe

Export the prior-auth-ready clinical brief with rationale, dosing, and payer documentation. Direct to EMR or share with the patient.

Market validation

The playbook is proven in oncology.

Three precision-medicine platforms in oncology have validated the model. Same three-channel non-exclusive structure Munus runs in autoimmune.

Tempus AI · NASDAQ: TEM[5]
$700M
ARR · $8–12B market cap · 30%+ YoY growth · 5 non-exclusive big-pharma partners.
Foundation Medicine[6]
$2.4B
Acquired by Roche in 2018. Companion diagnostic + non-exclusive pharma data partnerships.
Flatiron Health[7]
$1.9B
Acquired by Roche in 2018. Real-world oncology data and analytics platform.
Why Munus wins

An empty quadrant, a defensible algorithm, a built moat.

First-mover in autoimmune

Tempus and Foundation own oncology. Recursion and Insitro own drug discovery. No incumbent owns autoimmune + point-of-care. That's the Munus quadrant — and it's a $30–40B market.

Multi-modal inference engine

Most precision medicine is genomic only. Munus integrates pathway phenotype, prior drug-response history, exposure signature, and symptom pattern into a single inference layer that no genomic-only competitor can match.

Three customers · one algorithm

Same algorithm packaged for clinicians ($1,200/test, billable via existing decision-support codes), pharma (target BD partnerships $5–50M, non-exclusive), and payers (target enterprise contracts $0.1–10M/yr). The Tempus playbook applied to autoimmune.

Live customer cohort

The Gut Health Solution clinic is Munus's first customer. Real cases generate the real-world outcomes data flywheel that pharma and payers will pay to access in Phase 2 and Phase 3.

References

Sources for every claim on this page.

  1. Singh S, Murad MH, Fumery M, et al. Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease and ulcerative colitis: a systematic review and network meta-analysis. Am J Gastroenterol. 2020. Phase 3 readouts referenced include CHARM (adalimumab), UNITI (ustekinumab), GEMINI (vedolizumab), and ADVANCE/MOTIVATE (risankizumab). PubMed search ↗
  2. Park KT, Ehrlich OG, Allen JI, et al. The cost of inflammatory bowel disease: an initiative from the Crohn's & Colitis Foundation. Inflamm Bowel Dis. 2020. Plus CMS Part B/D biologic utilization data and AGA Cost of Care Initiative reports. AGA Clinical Guidance ↗
  3. IQVIA Institute / EvaluatePharma global biologics market reports (autoimmune segment). Industry-standard tracked spend data. IQVIA Institute ↗ · Grand View Research IBD market ↗
  4. Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390:2769–2778. PMID: 29050646. PubMed ↗ · Lancet abstract ↗
  5. Tempus AI, Inc. Annual Report (Form 10-K), Fiscal Year 2024. NASDAQ: TEM. Tempus Investor Relations ↗
  6. F. Hoffmann-La Roche AG. Press release: Roche to acquire Foundation Medicine. April 2018. Roche press release ↗
  7. F. Hoffmann-La Roche AG. Press release: Roche to acquire Flatiron Health to accelerate industry-wide development and delivery of breakthrough medicines for patients with cancer. February 15, 2018. Roche press release ↗

Talk to us.

Munus is raising a seed round. We're open to investor conversations, clinical pilot partnerships, and KOL advisor introductions.

Or email josh@munus.health directly.